What is the difference between vaccine and immunoglobulin

Since blood screening and testing began, there have been no reports of blood-borne infections such as HIV, hepatitis B or hepatitis C in people who received RabIg.

If an animal that may have rabies has bitten or scratched you, get RabIg and rabies vaccine as soon as possible. If you have already had a complete series of rabies vaccine you do not need to get RabIg. RabIg is given by injection into the area s surrounding the wound. It is given at the same time as the 1st dose of rabies vaccine. Rabies vaccine is usually given as a series of 4 doses over a period of 14 days. You will receive the remaining doses of vaccine 3, 7 and 14 days later.

If you have a weakened immune system or are taking chloroquine, you will get a 5th dose of the vaccine 28 days after the 1st dose. For those with a weakened immune system, you need a blood test 7 to 14 days after the 5th dose of vaccine to determine that you are protected. If the blood test indicates that you are not protected you will need a second series of vaccine. If you completed a rabies vaccine series before being exposed to the rabies virus you should get 2 doses of the vaccine.

These doses are given 3 days apart. The rabies vaccine can also be given to prevent rabies before exposure to the rabies virus. The vaccine is recommended, but not provided free, for those at risk of being exposed to the rabies virus, including:. The vaccine is given as a series of 3 doses.

The 2nd dose is given 7 days after the 1st dose. The 3rd dose is given 21 to 28 days after the 1st dose. RabIg and rabies vaccine prevent rabies disease, which is almost always fatal. RabIg provides immediate, short-term protection against infection with the rabies virus. It is not known if the vaccine is secreted in human milk, but any vaccine present in breast milk should not have harmful effects.

For mild side effects such as headache, muscle soreness or fever, paracetamol may be taken every four hours up to a maximum for adults of eight mg tablets in 24 hours. If fever persists or you are concerned about your condition consult your doctor. When recommended, HRIG is usually given with the first dose of the vaccine. It provides immunity until the vaccine starts to protect at about day 7. It is preferable that as much as possible of the HRIG is injected in and around the wound site.

Pain and discomfort can occur at the injection site. Fever and chills sometimes occur. As with all medicines, acute severe allergic reactions occur very rarely. Because HRIG is prepared from human blood, the risk of transmitting blood-borne infections cannot be absolutely excluded. This risk also applies to as yet unknown diseases. The risk of spreading known diseases is reduced during the production of HRIG by screening blood donors, by screening all donated blood for HIV, hepatitis B and hepatitis C, and by further processing of the blood to extract the immunoglobulins.

Immune globulin is available to treat hepatitis A and hepatitis B. Sign up for our Health Tip of the Day newsletter, and receive daily tips that will help you live your healthiest life. Mayo Clinic. Drugs and Supplements.

Hepatitis B Immunoglobulin. Centers for Disease Control. Immunization: You Call the Shots. Use of Immune Globulin. Adverse Effects of Immunoglobulin Therapy. Immune Globulin. Reviewed: September 20, Arumugham VB, Rayi A. In: StatPearls [Internet].

Your Privacy Rights. To change or withdraw your consent choices for VerywellHealth. At any time, you can update your settings through the "EU Privacy" link at the bottom of any page. These choices will be signaled globally to our partners and will not affect browsing data. However, cellular immune responses, which are more difficult to measure, are also an important aspect of vaccine responses. This chapter introduces the clinical use of vaccines and immunoglobulins.

Agents with a limited use, such as agents for bioterrorism or travel, are beyond the scope of this chapter. Vaccines induce active immunity—that is, immunity generated Your MyAccess profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'.

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